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Although these monoamines would normally be metabolised by MAO buy cheap dutas 0.5mg line, they are conserved when a MAO inhibitor (MAOI) is present, and so co-administration of reserpine and a MAOI leads to accumulation of monoamines in the neuronal cytosol. It is now known that, when the concentration of cytoplasmic monoamines is increased in this way, they are exported to the synapse on membrane-bound monoamine trans- porters. The ensuing increase in monoamine transmission, despite the depletion of the vesicular pool, presumably accounts for the effects of iproniazid on the behaviour of reserpine-pretreated rats. In 1958, another agent, imipramine, was discovered by chance to have beneficial effects in depression. Drawing all this evidence together, Schildkraut (1965) concluded that depression was caused by a functional deficit of noradrenergic transmission in the brain. He also thought that the rebound depression and fatigue, which are experienced after the arousing effects of amphetamine have worn off, were due to depletion of neuronal stores of noradrenaline. To this day, there is controversy over whether or not amphetamine has a beneficial effect in depression. One suggested that there is a malfunction of neurons which release 5-HT (Coppen 1967). Another proposed that a deficit in both noradrenergic and serotonergic transmission is to blame (Maas 1975). Others have argued that an imbalance in the functional output of these two systems is the key factor (Ricci and Wellman 1990). However, they all share a common theme: that disruption of some aspect of monoaminergic transmission in the brain is a causal factor in depression. It is remarkable that, although this theory is often challenged, it has not yet been replaced by a validated alternative and, to this day, central noradrenergic and/or serotonergic systems are primary targets for all established antidepressant drugs. THE NEUROBIOLOGY OF DEPRESSION Attempts to find the cause(s) of depression have adopted two main approaches. One is to lookfor the neurobiological basis of depression in human subjects and animal models of this condition. The second is to investigate the pharmacology of established antidepressant agents to see whether they consistently augment some, and ideally the same, neurobiological targets in the brain.

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Generally the vesicles at these axo-axonic synapses are flattened (or disk-like) but some have spherical vesicles and so while the situation is not resolved vesicle shape tends to be linked with the NT they house safe dutas 0.5 mg. In the lateral superior olive, antibody studies have shown four types of axon terminal with characteristic vesicles (Helfert et al. Those with round vesicles contain glutamate, those with flattened vesicles have glycine, while large plemorphic vesicles contain glycine and GABA and small plemorphic ones only GABA. Interestingly when GABA and glycine were found in the same terminals in the spinal cord, the post- synaptic membrane had receptors to both NTs. If NTs can have distal non-synaptic effects then nerve terminals that do not make definite synaptic connections could be apparent. In smooth muscle the noradrenergic fibres ramify among and along the muscle fibres apparently releasing noradrenaline from swellings (varicosities) along their length rather than just at distinct terminals. In the brain many aminergic terminals also originate from en passant fibres but it seems that not all of them form classical synaptic junctions. Monoamines can also be found in terminals at both symmetric and asymmetric synapses, but this may be partly because they co-exist with the classical transmitters glutamate and GABA. The fact that vesicular and neuronal uptake transporters for the monoamines can be detected outside a synapse along with appropriate postsynaptic receptors does suggest, however, that some monoamine effects can occur distant from the synaptic junction (see Pickel, Nirenberg and Milner 1996, and Chapter 6). For further details on the concept of synaptic transmission and the morphology of synapses see Shepherd and Erulkar (1997) and Peters and Palay (1996) respectively. NEUROTRANSMITTER ORGANISATION AND UTILISATION In the periphery at the mammalian neuromuscular junction each muscle fibre is generally influenced by only one nerve terminal and the one NT acts on one type of receptor localised to a specific (end-plate) area of the muscle. The system is fitted for the induction of the rapid short postsynaptic event of skeletal muscle fibre contraction and while the study of this synapse has been of immense value in elucidating some basic concepts of neurochemical transmission it would be unwise to use it as a universal template of synaptic transmission since it is atypical in many respects.

Also cheap dutas 0.5mg online, because of decussation (crossing- over), somatic information from each side of the body is projected Knowledge Check to the postcentral gyrus of the contralateral cerebral hemisphere. List the different types of cutaneous receptors and state All somatic information from the same area of the where they are located. What portion of the brain inter- body projects to the same area of the postcentral gyrus. List the receptors that that receive sensory information from different parts of the body respond to pain and the structures of the brain that (see fig. Such a map is greatly distorted, however, be- are particularly important in the perception of pain cause it shows larger areas of cerebral cortex devoted to sensation sensation. The dis- proportionately large areas of the caricature-like sensory ho- 8. Discuss why it is important for a physician that there is a higher density of sensory receptors in the face and to know the referred pain sites. Using a flow chart, describe the neural pathways leading from cutaneous pain and pressure receptors to the postcen- tral gyrus. Sensory Organs © The McGraw−Hill Anatomy, Sixth Edition Coordination Companies, 2001 Chapter 15 Sensory Organs 495 FIGURE 15. Olfac- tion functions closely with gustation (taste) in that the receptors Olfactory receptors are the dendritic endings of the olfactory nerve for both are chemoreceptors, which require dissolved substances (I) that respond to chemical stimuli and transmit the sensation of for stimuli. Olfactory receptor cells are located in the nasal mucosa within the roof of the nasal cavity on both sides of the nasal sep- Objective 8 Describe the sensory pathway for olfaction. Olfactory cells are moistened by the surrounding glandular goblet cells. The cell bodies of the bipolar olfactory Olfactory reception in humans is not highly developed compared cells lie between the supporting columnar cells. Because we do not rely on each olfactory cell contains several dendritic endings, called smell for communicating or for finding food, the olfactory sense olfactory hairs that constitute the sensitive portion of the recep- is probably the least important of our senses. These unmyelinated dendritic endings respond to air- in detecting the presence of an odor rather than its intensity.

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